Piritramide—A New Long-acting Analgesic

RELATIONSHIPS BETWEEN LIPOPHILIC CHARACTER AND BIOLOGICAL ACTIVITY OF NEW POTENTIAL LONG-ACTING LOCAL ANESTHETICS

The partition coefficients (P-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. These are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. Their aqueous solutions have shown different absorption maxima, and these have been use...

Cefovecin: a new long-acting cephalosporin

Long-acting sulfonylureas -- long-acting hypoglycaemia.

long-acting antipsychotics

long-acting (depot) anti-psychotic injection (lai) is an essential component of the treatment of schizophrenia. in this editorial, the journal tries to give a short account of the current ideas and practical aspects of lai, with respect to the iranian experience. two categories of the long-acting injections are discussed mainly regarding their dosage, intervals of their injections and availabil...

HS-599: a novel long acting opioid analgesic does not induce place-preference in rats.

1. When administered subcutaneously HS-599, a new didehydroderivative of buprenorphine (18,19-dehydrobuprenorphine), produced a long-lasting antinociceptive response in rats. Its potency exceeded twice that of buprenorphine. In the tail-flick test it acted as a full agonist but in the plantar test only as a partial agonist. Whereas the mu-opioid antagonists naloxone and naltrexone antagonized H...